Nucleic Acid Synthesis
Medchemexpress LLC Gemcitabine-o-si(di-iso)-o-mc | 98.8% | 558.65 g·mol⁻1 | C24H36F2N4O7Si | 5 MG
Gemcitabine-O-Si(di-iso)-O-Mc is a gemcitabine-based drug-linker conjugate supplied for antibody-drug conjugate research. It couples the cytotoxic nucleoside analog gemcitabine to an Si(di-iso)-based ADC linker and is provided as a characterized, research-grade reagent.
- Intended for antibody-drug conjugate research and development.
- Reported purity 98.8%.
- Molecular weight 558.65 g·mol⁻1 and formula C24H36F2N4O7Si.
- Available in small-mass quantities suitable for lab-scale use.
- Provided with batch-specific certificate of analysis.
Medchemexpress LLC 2'-O-(2-methoxyethyl)-uridine | 223777-15-9 | 99.2% | 302.28 | C12H18N2O7 | 100 MG
2'-O-(2-methoxyethyl)-uridine is a 2'-modified uridine nucleoside analog used in research. It is a synthetic derivative of uridine employed in studies of nucleoside analogs and has potential application in chemotherapeutic agent development.
- High purity suitable for research use (99.2%).
- Molecular weight 302.28; chemical formula C12H18N2O7.
- Soluble in DMSO (100 mg/mL; may require sonication).
- Storage: solid at 4°C protected from light; in solution store at -80°C up to 6 months or -20°C up to 1 month.
- Available as a 100 MG solid quantity and in other sizes for research applications.
Medchemexpress LLC 2′-O-Methyluridine | 2140-76-3 | 99.8% | 258.23 | 1 ML
2′-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. Studies have shown that 2′-O-Methyluridine levels in serum are decreased in patients with breast cancer. It is intended for research use only and not for sale to patients.
- Modified nucleoside.
- Naturally present in T. thermophile tRNA.
- Serum levels are decreased in breast cancer patients, suggesting potential diagnostic or prognostic implications.
- Can be incorporated into siRNA for gene silencing studies, demonstrated by its use in siRNA targeting apolipoprotein B to reduce ApoB protein levels in HepG2 cells and prevent IFN-α production in isolated human PBMCs.
- Appearance: solid, white to off-white.
- Storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
- Storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month.
eMolecules 88847-89-6 | 8-OXO-2'-DEOXYGUANOSINE | MFCD03788705 | 0.25g
AstaTech | 8-OXO-2'-DEOXYGUANOSINE | 0.25g | 575799851 | 40087 | 95.000 | 88847-89-6 | MFCD03788705 | 283.244 | C10H13N5O5
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Cambridge Isotope Laboratories XANTHOSINE-5'-MONOPHOSPHATE, AMMONIUM SALT (13C10, 98%)CHEM PUR. >90% (IN SOLN), 100 UMOL
XANTHOSINE-5'-MONOPHOSPHATE, AMMONIUM SALT (13C10, 98%)CHEM PUR. >90% (IN SOLN), 100 UMOL
Medchemexpress LLC Trifluridine/tipiracil hydrochloride mixture | 733030-01-8 | 99.98% | 435.76 | 100 MG
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. It is a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). This mixture primarily exhibits its antitumor activity by inhibiting thymidylate synthase (TS) and incorporating into DNA. It prevents body weight loss and reduces relative tumor volume in colorectal cancer and gastric cancer mouse models.
- Potent and orally active nucleoside antitumor agent.
- Composition: 1:0.5 molar mixture of FTD and TPI.
- Mechanism of action: inhibition of thymidylate synthase (TS) and incorporation into DNA.
- Prevents body weight loss and reduces relative tumor volume in colorectal cancer and gastric cancer mice models.
Apexbio Technology LLC Clofarabine 123318-82-1 25mg
Clofarabine (CAS 123318-82-1) is a nucleoside analogue that inhibits DNA synthesis by acting as a substrate for deoxycytidine kinase (dCK) a cytosolic enzyme involved in the DNA salvage pathway Intracellularly clofarabine undergoes phosphorylation to its triphosphate form which competes with dATP for DNA polymerase- and - and inhibits ribonucleotide reductase with an IC50 of 65 nM thereby decreasing dCTP and dATP pools Its monophosphate metabolite can be incorporated into DNA impeding strand elongation and repair Clofarabine is efficiently transported into cells via nucleoside transporters (hENT1 hENT2 hCNT2) and induces apoptosis through the release of cytochrome c APAF1 AIF and caspase-9 In vivo clofarabine exhibits pronounced antitumor activity in mouse xenograft models
Cayman Chemical 6-thIo-2-DeoxygunosIn 1mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Cayman Chemical ArachIdonyl thIo-PC 10mg
A chromogenic substrate for many PLA2s including sPLA2, cPLA2, and iPLA2
Cayman Chemical ArachIdonyl thIo-PC 5mg
A chromogenic substrate for many PLA2s including sPLA2, cPLA2, and iPLA2
Cayman Chemical XnthosIn 5-monphosphate 100mg
An intermediate in purine metabolism, the product of the rate limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis.
Medchemexpress LLC 2'-C-methyluridine | 31448-54-1 | MFCD02682960 | ≥97.0% | 258.23 g/mol | C10H14N2O6 | 5 G
2'-C-methyluridine is a modified uridine nucleoside used in biochemical and pharmacological research as a nucleoside analog. It is provided as a stable powder for experimental use in studies of nucleoside metabolism, antiviral activity, and medicinal chemistry.
- High purity (≥97.0%).
- Molecular formula C10H14N2O6; molecular weight 258.23 g/mol.
- Supplied as a white to off-white powder for easy handling.
- Recommended storage: powder -20°C long-term, 4°C short-term; in solvent -80°C for extended storage.
- Suitable for biochemical, antiviral, and medicinal chemistry applications.
- Available in multiple pack sizes to support small-scale and larger studies.
Cayman Chemical thIo-p-ToluamIde 1g
A cyclic thioamide building block used in drug discovery chemistry
eMolecules 2'-Deoxy-5-fluorocytidine | 10356-76-0 | MFCD00077348 | 1g
Combi-Blocks | 2'-Deoxy-5-fluorocytidine | 1g | 249364242 | QG-9600 | 98.000 | 10356-76-0 | MFCD00077348 | 245.210 | C9H12FN3O4
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC HY-19528 10mg Medchemexpress, SAH CAS:979-92-0 Purity:>98%
Medchemexpress, HY-19528 10mg SAH CAS:979-92-0 SAH is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.